A bolus of 30 μg.kg-1 fentanyl was given to 9 preterm infants (gestational age 31.8 ± 4.7 weeks, weight 1100 ± 309 g) for induction of anesthesia for ligation of a patent ductus arteriosus. Thirty minutes after the injection, fentanyl plasma concentrations were between 7.7 and 13.6 ng.ml-1. Elimination half-life was 6-32 hr (mean ± SD, 17.7 ± 9.3). Systolic blood pressure remained stable throughout surgery. There was a gradual increase in heart rate from 159 ± 12 min-1 at the time of skin incision to 173 ± 15 min-1 at the time of skin closure (P < 0.05). Fentanyl plasma concentrations remained virtually unchanged between 30 min (10.6 ± 1.9 ng.ml-1) and 120 min (9.6 ± 1.6 ng.ml-1); whereas at the end of surgery most infants moved and breathed spontaneously. This phenomenon can be explained by redistribution of fentanyl from brain into pharmacodynamically inert tissues.
CITATION STYLE
Collins, C., Koren, G., Crean, P., Klein, J., Roy, W. L., & MacLeod, S. M. (1985). Fentanyl pharmacokinetics and hemodynamic effects in preterm infants during ligation of patent ductus arteriosus. Anesthesia and Analgesia, 64(11), 1078–1080. https://doi.org/10.1213/00000539-198511000-00007
Mendeley helps you to discover research relevant for your work.