OBJECTIVE:: This study examined the effect of basic fibroblast growth factor (FGF)-2 with an absorbable collagen sponge on angiogenesis and bone regeneration in rat calvarial critical-sized bone defects using microcomputed tomography. METHODS:: Forty 7-week-old male Fischer rats were used. The symmetrical critical-sized calvarial bone defects (5 mm diameter) were created. An absorbable collagen sponge with or without FGF-2 (0.1% or 0.3%) was implanted into each bone defect. RESULTS:: Blood vessel and bone volumes were significantly higher in the 0.3% FGF-2 group compared with the control and 0.1% FGF-2 groups on day 28. Significantly more osteoblast- and osteoclast-like cells were seen in the 0.3% FGF-2 group. CONCLUSIONS:: Thus, FGF-2 increased blood vessel and bone formation in rat calvarial critical-sized bone defects. Copyright © 2013 by Lippincott Williams & Wilkins.
CITATION STYLE
Kigami, R., Sato, S., Tsuchiya, N., Yoshimakai, T., Arai, Y., & Ito, K. (2013). FGF-2 angiogenesis in bone regeneration within critical-sized bone defects in rat calvaria. Implant Dentistry, 22(4), 422–427. https://doi.org/10.1097/ID.0b013e31829d19f0
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