A finite element model for epidermal wound healing

  • Vermolen F
  • Adam J
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Abstract

A finite element model for epidermal wound healing is proposed. The model takes into account the sequential steps of angiogenesis (neo-vascularization) and wound contraction (the actual healing of a wound). An innovation in the present study is the combination of both partially overlapping processes, yielding novel insights into the process of wound healing. The models consist of nonlinearly coupled diffusion-reaction equations, in which transport of oxygen, growth factors and epidermal cells and mitosis are taken into account.

Author-supplied keywords

  • PDE
  • finite element
  • neo-vascularization
  • wound contraction

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Authors

  • F J Vermolen

  • J A Adam

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