First documented cure of a suggestive exogenous reinfection in polymyositis with same but multidrug resistant M. tuberculosis

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Abstract

Background: MDR Mycobacterium tuberculosis is the major cause of treatment failure in tuberculosis patients, especially in immunosuppressed. We described a young polymyositis patient on immunosuppressive therapy who was started with antituberculosis therapy as a susceptible strain of M. tuberculosis was isolated from a single cutaneous abscess in his neck and from regional lymph nodes. Case presentation: He had non-reactive miliary tuberculosis and multiple cutaneous abscesses 6 months later with the same strain, which was resistant this time to 9 antituberculosis drugs. We described clinical presentation, radiological and laboratory work-up, treatment and follow-up as the patient was cured after 1.5 years with 6 antituberculosis drugs. Conclusion: To our knowledge, this is the first reported case where an immunosuppressed patient with suggestive exogenous reinfection within 6 months with the same but MDR strain of M. tuberculosis was cured. Intense management and regular follow up were important since the patient was a potent source of MDR M. tuberculosis infection and there was limited choice for therapy. © 2004 Mukhopadhyay et al; licensee BioMed Central Ltd.

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Mukhopadhyay, C., Garg, A., & Ayyagari, A. (2004). First documented cure of a suggestive exogenous reinfection in polymyositis with same but multidrug resistant M. tuberculosis. BMC Infectious Diseases, 4. https://doi.org/10.1186/1471-2334-4-63

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