Fish: A suitable system to model human bone disorders and discover drugs with osteogenic or osteotoxic activities

  • Laizé V
  • Gavaia P
  • Cancela M
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Abstract

This review discusses the suitability and advantages of teleost fish for studying underlying mechanisms of normal and pathological development and mineralization of vertebrate skeleton, presents a selection of zebrafish mutants and transgenic lines modeling human skeletal diseases and highlights currently available fish systems for identifying and characterizing novel osteogenic and osteotoxic molecules.

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