Fluoride excess and periostitis in transplant patients receiving long-term voriconazole therapy

  • Wermers R
  • Cooper K
  • Razonable R
 et al. 
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We describe a heart transplant patient with painful periostitis and exostoses who was receiving long-term therapy with voriconazole, which is a fluoride-containing medication. Elevated plasma and bone fluoride levels were identified. Discontinuation of voriconazole therapy led to improvement in pain and reduced fluoride and alkaline phosphatase levels.

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  • Robert A. Wermers

  • Kay Cooper

  • Raymund R. Razonable

  • Paul J. Deziel

  • Gary M. Whitford

  • Walter K. Kremers

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