Focal adhesion kinase: targeting adhesion signaling pathways for therapeutic intervention.

  • Parsons J
  • Slack-Davis J
  • Tilghman R
 et al. 
  • 29

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Abstract

The tumor microenvironment plays a central role in cancer progression and metastasis. Within this environment, cancer cells respond to a host of signals including growth factors and chemotactic factors, as well as signals from adjacent cells, cells in the surrounding stroma, and signals from the extracellular matrix. Targeting the pathways that mediate many of these signals has been a major goal in the effort to develop therapeutics.

Author-supplied keywords

  • Antineoplastic Agents
  • Antineoplastic Agents: therapeutic use
  • Disease Progression
  • Focal Adhesion Protein-Tyrosine Kinases
  • Focal Adhesion Protein-Tyrosine Kinases: antagonis
  • Focal Adhesion Protein-Tyrosine Kinases: genetics
  • Focal Adhesion Protein-Tyrosine Kinases: physiolog
  • Humans
  • Integrins
  • Integrins: physiology
  • Neoplasm Metastasis
  • Neoplasms
  • Neoplasms: drug therapy
  • Neoplasms: enzymology
  • Neoplasms: pathology
  • Neoplasms: physiopathology
  • Oligonucleotides, Antisense
  • Oligonucleotides, Antisense: therapeutic use
  • Protein Kinase Inhibitors
  • Protein Kinase Inhibitors: therapeutic use
  • RNA, Small Interfering
  • RNA, Small Interfering: genetics
  • Signal Transduction

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Authors

  • J Thomas Parsons

  • Jill Slack-Davis

  • Robert Tilghman

  • W Gregory Roberts

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