Food deprivation alters dopamine utilization in the rat prefrontal cortex and asymmetrically alters amphetamine-induced rotational behavior

  • Carlson J
  • Glick S
  • Hinds P
 et al. 
  • 9

    Readers

    Mendeley users who have this article in their library.
  • 49

    Citations

    Citations of this article.

Abstract

The effects of 24 and 48 h of food deprivation on changes in the activity of dopaminergic (DAergic) neurons and d-amphetamine-induced rotational behavior were studied in male and female Long-Evans rats. Food deprivation selectively altered 3,4-dihydroxyphenylacetic acid (DOPAC) in the medial prefrontal cortex (PFC) but not in the nucleus accumbens or striatum: PFC DOPAC was significantly increased and decreased bilaterally after 24 and 48 h of food deprivation, respectively. Left > right hemispheric asymmetries were seen for DOPAC and DOPAC/DA in the control animals. In a separate experiment, 24 h of food deprivation enhanced right rotational behavior, while 48 h significantly increased left rotational behavior. The results are discussed in terms of food deprivation's effects on mesocortical DAergic neurons, previous work on cortical modulation of striatal function and how these effects on rotational behavior may be determined by brain asymmetry. © 1988.

Author-supplied keywords

  • Brain asymmetry
  • Dopamine
  • Food deprivation
  • Medial prefrontal cortex
  • Rotational behavior
  • d-Amphetamine

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Jeffrey N. Carlson

  • Stanley D. Glick

  • Patricia A. Hinds

  • John L. Baird

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free