Forkhead transcription factors: new insights into protein kinase B (c- akt) signaling

  • Kops G
  • Burgering B
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The proto-oncogene protein kinase B (PKB), also known as c-Akt, is a central player in a signaling pathway of which many components have been linked to tumorigenesis. Active forms of PKB as well as of its upstream activator phosphatidylinositol 3-kinase (PI3K) have been found to be responsible for the transforming activities of certain viruses, and the negative regulator of this pathway, PTEN, is a tumor suppressor. The identification of particular downstream targets of PKB has provided us with new insights into the possible mechanism of PI3K/PKB-mediated tumorigenicity. Recently a subfamily of Forkhead transcription factors was identified as additional targets for PI3K/PKB signaling. This review discusses the studies that have led to this conclusion and the possible implications of this finding for our understanding of how PI3K/PKB activity could lead to oncogenesis.

Author-supplied keywords

  • *Signal Transduction
  • Amino Acid Sequence
  • Animal
  • Genes, Suppressor, Tumor
  • Human
  • Molecular Sequence Data
  • Nuclear Proteins/genetics/*physiology
  • Protein-Tyrosine Kinase/*physiology
  • Proto-Oncogene Proteins/genetics/*physiology
  • Transcription Factors/genetics/*physiology
  • Transcription, Genetic

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  • G J Kops

  • B M Burgering

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