Forkhead transcription factors: new insights into protein kinase B (c- akt) signaling

  • Kops G
  • Burgering B
  • 1

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

The proto-oncogene protein kinase B (PKB), also known as c-Akt, is a central player in a signaling pathway of which many components have been linked to tumorigenesis. Active forms of PKB as well as of its upstream activator phosphatidylinositol 3-kinase (PI3K) have been found to be responsible for the transforming activities of certain viruses, and the negative regulator of this pathway, PTEN, is a tumor suppressor. The identification of particular downstream targets of PKB has provided us with new insights into the possible mechanism of PI3K/PKB-mediated tumorigenicity. Recently a subfamily of Forkhead transcription factors was identified as additional targets for PI3K/PKB signaling. This review discusses the studies that have led to this conclusion and the possible implications of this finding for our understanding of how PI3K/PKB activity could lead to oncogenesis.

Author-supplied keywords

  • *Signal Transduction
  • Amino Acid Sequence
  • Animal
  • Genes, Suppressor, Tumor
  • Human
  • Molecular Sequence Data
  • Nuclear Proteins/genetics/*physiology
  • Protein-Tyrosine Kinase/*physiology
  • Proto-Oncogene Proteins/genetics/*physiology
  • Transcription Factors/genetics/*physiology
  • Transcription, Genetic

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

There are no full text links

Authors

  • G J Kops

  • B M Burgering

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free