The formal synthesis of (þ)-sorangicin A was completed by two independent routes. Both approaches feature a cross metathesis reaction to form the C29C30 bond to arrive at the bicyclic ether/tetrahydropyran fragment. Formation of the C15C16 olefin to unite the dihydropyran fragment with the rest of the molecule was achieved by either a cross metathesis reaction or a JuliaKocienski olefination.
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