Frequent BRG1/SMARCA4-Inactivating mutations in human lung cancer cell lines

  • Medina P
  • Romero O
  • Kohno T
 et al. 
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Abstract

Components of the SWI/SNF chromatin-remodeling complex, such as INI1, are inactivated in human cancer and, thus, act as tumor suppressors. Here we screened for mutations the entire coding sequence of BRG1 (SMARCA4), which encodes the ATPase of the complex, in 59 lung cancer cell lines of the most common histopathological types. Mutations were detected in 24% of the cancer cell lines, many of them in cells commonly used for lung cancer research. All mutations were homozygous and most predicted truncated proteins. The alterations were significantly more frequent in the non-small-cell lung cancer (NSCLC) type (13/37, 35%) as compared to the small-cell lung cancer (SCLC) type (1/19, 5%) (P

Author-supplied keywords

  • BRG1
  • Chromatin remodeling
  • Lung cancer
  • Myc amplification
  • SMARCA4
  • Tumor suppressor gene

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