Fresh blood for transfusion: how old is too old for red blood cell units?

  • Willy A. Flegel
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Available evidence currently precludes any firm conclusion, as to whether the transfusion of fresher red blood cell (RBC) units has advantages over older RBC units with regard to clinical outcome, including morbidity or mortality. Some chronically transfused patients receive fresh RBC units under the assumption that the RBC in vivo survival time is longer, extending the transfusion intervals and reducing the total number of RBC units transfused, with its concomitant adverse clinical effects such as iron overload. (...)

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  • Willy A. Flegel

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