Functional classification of memory CD8(+) T cells by CX3CR1 expression

  • Bottcher J
  • Beyer M
  • Meissner F
 et al. 
  • 5


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Localization of memory CD8(+) T cells to lymphoid or peripheral tissues is believed to correlate with proliferative capacity or effector function. Here we demonstrate that the fractalkine-receptor/CX3CR1 distinguishes memory CD8(+) T cells with cytotoxic effector function from those with proliferative capacity, independent of tissue-homing properties. CX3CR1-based transcriptome and proteome-profiling defines a core signature of memory CD8(+) T cells with effector function. We find CD62L(hi)CX3CR1(+) memory T cells that reside within lymph nodes. This population shows distinct migration patterns and positioning in proximity to pathogen entry sites. Virus-specific CX3CR1(+) memory CD8(+) T cells are scarce during chronic infection in humans and mice but increase when infection is controlled spontaneously or by therapeutic intervention. This CX3CR1-based functional classification will help to resolve the principles of protective CD8(+) T-cell memory.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • J P Bottcher

  • M Beyer

  • F Meissner

  • Z Abdullah

  • J Sander

  • B Hochst

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free