The functional valency of dodecamannosylated fullerenes with Escherichia coli FimH - Towards novel bacterial antiadhesives

  • Durka M
  • Buffet K
  • Iehl J
 et al. 
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Abstract

Fullerene hexakis-adducts bearing 12 peripheral mannose moieties have been prepared by grafting sugar derivatives onto the fullerene core and assayed as inhibitors of FimH, a bacterial adhesin, using isothermal titration calorimetry, surface plasmon resonance and hemagglutination assays.

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Authors

  • Maxime Durka

  • Kevin Buffet

  • Julien Iehl

  • Michel Holler

  • Jean Franois Nierengarten

  • Joemar Taganna

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