The fungal pattern recognition receptor, Dectin-1, and the associated cluster of C-type lectin-like receptors

  • Huysamen C
  • Brown G
  • 86


    Mendeley users who have this article in their library.
  • 62


    Citations of this article.


The mammalian natural killer gene complex (NKC) contains several families of type II transmembrane C-type lectin-like receptors (CLRs) that are best known for their involvement in the detection of virally infected or transformed cells, through the recognition of endogenous (or self) proteinacious ligands. However, certain CLR families within the NKC, particularly those expressed by myeloid cells, recognize structurally diverse ligands and perform a variety of other immune and homoeostatic functions. One such family is the 'Dectin-1 cluster' of CLRs, which includes MICL, CLEC-2, CLEC12B, CLEC9A, CLEC-1, Dectin-1 and LOX-1. Here, we review each of these CLRs, exploring our current understanding of their ligands and functions and highlighting where they have provided new insights into the underlying mechanisms of immunity and homeostasis.

Author-supplied keywords

  • C-type lectin
  • Homeostasis
  • ITAM
  • ITIM
  • Myeloid cells
  • Signaling

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Cristal Huysamen

  • Gordon D. Brown

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free