Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

  • Corder E
  • Saunders A
  • Strittmatter W
 et al. 
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The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-epsilon 4 alleles in 42 families with late onset AD. Thus APOE-epsilon 4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-epsilon 4 was virtually sufficient to cause AD by age 80.

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  • E. H. Corder

  • A. M. Saunders

  • W. J. Strittmatter

  • D. E. Schmechel

  • P. C. Gaskell

  • G. W. Small

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