X-linked agammaglobulinaemia (XLA) is a human immunodeficiency caused by failure of pre-B cells in the bone marrow to develop into circulating mature B cells. A novel gene has been isolated which maps to the XLA locus, is expressed in B cells, and shows mutations in families with the disorder. The gene is a member of the src family of proto-oncogenes which encode protein-tyrosine kinases. This is, to our knowledge, the first evidence that mutations in a src-related gene are involved in human genetic disease. © 1993 Nature Publishing Group.
CITATION STYLE
Vetrie, D., Vořechovský, I., Sideras, P., Holland, J., Davies, A., Flinter, F., … Bentley, D. R. (1993). The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases. Nature, 361(6409), 226–233. https://doi.org/10.1038/361226a0
Mendeley helps you to discover research relevant for your work.