Gene Recombination in the Bacterium Escherichia coli

  • Tatum E
  • Lederberg J
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Abstract

The study of inheritance in bacteria has, for the most part, been confined to the investigation. of mutational changes in the course of clonal reproduction. With the exception of experiments on pneumococcus type transformations there have been few studies on the direct hereditary interaction of one bacterial type with another. The conception that bacteria have no sexual mode of reproduction is widely entertained. This paper will be devoted to the presentation of evidence for the occurrence in a bacterium of a process of gene recombination, from which the existence of a sexual stage may be inferred. On the basis of mutation studies many investigators have concluded that the hereditary properties of bacteria are based on the existence of genes (Luria and Delbruck, 1943; Roepke et al., 1944; Lwoff, 1941; Demerec and Fano, 1945; Gray and Tatum, 1944), although it is not clear whether these genes should be homologized with the Mendelian factors of higher organisms, or with the extra-nuclear factors which have been demonstrated in some microorganisms and higher plants (Sonneborn, 1943; Spiegelman et al., 1945; Rhoades, 1943). The genic basis of microbial inheritance does not depend on the demonstra-bility of a sexual phase in bacteria. However, more powerful genetic methods paralleling classical Mendelian analysis would be available if it were possible to follow the inheritance of characters in the products of a sexual fusion. The few examples of this approach thus far reported have provided no incontrover-tible evidence for sexual reproduction in bacteria. The phenomenon of paragglutination in the colon-typhoid-dysentery group might be regarded as an instance of bacterial hybridization, and was so inter-preted by Almquist (1924). As reported by numerous authors, paragglutination refers to the development of new types which react with antisera for each of

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  • BACTERIA/coli

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Authors

  • E. L. Tatum

  • J. Lederberg

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