Genetic Approaches to Neural Circuits in the Mouse

  • Josh Huang Z
  • Zeng H
  • 390


    Mendeley users who have this article in their library.
  • 85


    Citations of this article.


To understand the organization and assembly of mammalian brain circuits, we need a comprehensive tool set that can address the chal-lenges of cellular diversity, spatial complexity at synapse resolution, dy-namic complexity of circuit operations, and multifaceted developmen-tal processes rooted in the genome. Complementary to physics-and chemistry-based methods, genetic tools tap into intrinsic cellular and developmental mechanisms. Thus, they have the potential to achieve appropriate spatiotemporal resolution and the cellular-molecular speci-ficity necessary for observing and probing the makings and inner work-ings of neurons and neuronal circuits. Furthermore, genetic analysis will be key to unraveling the intricate link from genes to circuits to systems, in part through systematic targeting and tracking of individual cellular components of neural circuits. Here we review recent progress in genetic tool development and advances in genetic analysis of neural circuits in the mouse. We also discuss future directions and implications for understanding brain disorders.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Z. Josh Huang

  • Hongkui Zeng

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free