Genetic architecture of Hsp90-dependent drug resistance

  • Cowen L
  • Carpenter A
  • Matangkasombut O
 et al. 
  • 63


    Mendeley users who have this article in their library.
  • 90


    Citations of this article.


Hsp90 potentiates the evolution of azole resistance in the model yeast Saccharomyces cerevisiae and the opportunistic pathogen Candida albicans via calcineurin. Here, we explored effectors downstream of calcineurin regulating this Hsp90-dependent trait. Using S. cerevisiae erg3 mutants as a model, we determined that both Crz1 and Hph1 modulate azole resistance.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Leah E. Cowen

  • Anne E. Carpenter

  • Oranart Matangkasombut

  • Gerald R. Fink

  • Susan Lindquist

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free