Genetic basis for a mouse model of Down syndrome.

  • Reeves R
  • Gearhart J
  • Littlefield J
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Abstract

The trisomy 16 (Ts16) mouse has been proposed as a model for Down's syndrome (DS) in humans, based on genetic homology between mouse chromosome 16 (MMU 16) and human chromosome 21 (HSA 21). Translocations of HSA 21 resulting in trisomy for only a portion of the genetic information contained on this chromosome can result in a DS phenotype. Techniques for localizing genes on chromosomes have been used to identify the portion of MMU 16 that corresponds to the DS region of HSA 21. This region appears to be highly conserved between mouse and human, providing further support for a mouse model of DS. (PsycINFO Database Record (c) 2012 APA, all rights reserved)

Author-supplied keywords

  • Down's Syndrome
  • Genetics
  • Mice
  • Models
  • Trisomy
  • genetic basis for model of Down's syndrome
  • trisomy 16 mice

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Authors

  • Roger H Reeves

  • John D Gearhart

  • J W Littlefield

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