We present a formal language for specifying via constraints a "design space" of DNA constructs composed of genetic parts, and an algorithm for automatically and correctly creating a novel representation of the space of satisfying designs. The language is simple, captures a large class of design spaces, and possesses algorithms for common operations on design spaces. The flexibility of this approach is demonstrated using a 16-gene nitrogen fixation pathway and genetic logic circuits.
CITATION STYLE
Bhatia, S. P., Smanski, M. J., Voigt, C. A., & Densmore, D. M. (2017). Genetic Design via Combinatorial Constraint Specification. ACS Synthetic Biology, 6(11), 2130–2135. https://doi.org/10.1021/acssynbio.7b00154
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