Genetic diversity between and within the arenavirus species indigenous to western Venezuela

  • Fulhorst C
  • Cajimat M
  • Milazzo M
 et al. 
  • 36


    Mendeley users who have this article in their library.
  • 18


    Citations of this article.


The results of analyses of Z, RNA-dependent RNA polymerase, glycoprotein precursor, and nucleocapsid protein gene sequence data suggested that Guanarito virus was the most common cause of Venezuelan hemorrhagic fever in a 7-year period in the 1990s and that the evolution of Pirital virus in association with Sigmodon alstoni (Alston's cotton rat) has occurred at a significantly higher rate than the evolution of Guanarito virus in association with Zygodontomys brevicauda (short-tailed cane mouse) on the plains of western Venezuela. The results of analyses of the primary structures of the glycoproteins of the 8 strains of Guanarito virus isolated from humans suggested that these strains would be highly cross-reactive in neutralization assays. Thus, passive antibody therapy may prove beneficial in the treatment of human disease caused by strains of Guanarito virus that are enzootic in the region in which Venezuelan hemorrhagic fever is endemic. © 2008 Elsevier Inc. All rights reserved.

Author-supplied keywords

  • Arenaviral hemorrhagic fever
  • Arenaviridae
  • Guanarito virus
  • Passive antibody therapy
  • Pirital virus
  • Venezuelan hemorrhagic fever

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Charles F. Fulhorst

  • Maria N B Cajimat

  • Mary Louise Milazzo

  • Hector Paredes

  • Nuris M C de Manzione

  • Rosa A. Salas

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free