The mature eye is a complex organ that develops through a highly organized process during embryogenesis. Alterations in its genetic programming can lead to severe disorders that become apparent at birth or shortly afterwards; for example, one-half of the cases of blindness in children have a genetic cause. This review outlines the genetic basis of eye development, as determined by mutation analysis in patients and in model organisms. A better understanding of how this intricate organ develops at the genetic and cellular level is central to our understanding of the pathologies that afflict it.
CITATION STYLE
Graw, J. (2003, November). The genetic and molecular basis of congenital eye defects. Nature Reviews Genetics. https://doi.org/10.1038/nrg1202
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