Genetic polymorphisms of molecules involved in host immune response to dengue virus infection

  • Fang X
  • Hu Z
  • Shang W
 et al. 
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The dengue virus (DENV) belongs to the flavivirus family. Each of the four distinct serotypes of this virus is capable of causing human disease, especially in tropical and subtropical areas. The majority of people infected with DENV manifest asymptomatic or dengue fever with flu-like self-limited symptoms. However, a small portion of patients emerge with severe manifestations referred to as dengue hemorrhagic fever, which has a high mortality rate if not treated promptly. The host immune system, which plays important roles throughout the whole process of DENV infection, has been confirmed to have double-edged effects on DENV infection. Recently, much attention has been paid to the genetic heterogeneity of molecules involved in the host immune response to DENV infection. This heterogeneity has been proved to be the determining factor for DENV disease orientation. The present review discusses the primary functions and single nucleotide polymorphisms of some critical molecules in the human DENV immunological defense, especially the polymorphism locus associated with the DENV pathogenesis and disease susceptibility.

Author-supplied keywords

  • Animalia
  • Animals
  • Biochemistry and Molecular Biophysics
  • Chordata
  • Chordates
  • Clinical Immunology
  • Common
  • Flaviviridae
  • Genetics - General
  • Genetics - Human
  • Genetics of bacteria and viruses
  • Hominidae
  • Host
  • Human Medicine
  • Humans
  • Immunology - Immunopathology, tissue immunology
  • Infection
  • Mammalia
  • Mammals
  • Medical Sciences
  • Medical and clinical microbiology - Virology
  • Microorganisms
  • Molecular Genetics
  • Pathogen
  • Positive Sense Single-Stranded RNA Viruses
  • Positive Sense ssRNA Viruses
  • Primates
  • Species
  • Vertebrata
  • Vertebrates
  • Viral Disease
  • Virology - General and methods
  • Viruses

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  • Xin Fang

  • Zhen Hu

  • Weilong Shang

  • Junmin Zhu

  • Chuanshan Xu

  • Author Rao Reprint

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