Genetic susceptibility of the arterial wall is an important determinant of atherosclerosis in C57BL/6 and FVB/N mouse strains

  • Shim J
  • Handberg A
  • Östergren C
 et al. 
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Abstract

How genetic variations among inbred mouse strains translate into differences in atherosclerosis susceptibility is of significant interest for the development of new therapeutic strategies. The objective of the present study was to examine whether genetically controlled arterial wall properties influence atherosclerosis susceptibility in FVB/N (FVB) and C57BL/6 (B6) apolipoprotein E knockout (apoE(-/-)) mouse strains.

Author-supplied keywords

  • atherosclerosis
  • genetically altered mice

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Authors

  • Jacob BentzonAarhus Universitet Institut for Klinisk Medicin

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  • Jeong Shim

  • Aase Handberg

  • Caroline Östergren

  • Erling Falk

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