Genetic variants associated with myocardial infarction risk factors in over 8000 individuals from five ethnic groups: The INTERHEART Genetics Study

  • Anand S
  • Xie C
  • Pare G
 et al. 
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Abstract

BACKGROUND: Myocardial infarction (MI) is a leading cause of death globally, but specific genetic variants that influence MI and MI risk factors have not been assessed on a global basis. METHODS AND RESULTS: We included 8795 individuals of European, South Asian, Arab, Iranian, and Nepalese origin from the INTERHEART case-control study that genotyped 1536 single-nucleotide polymorphisms (SNPs) from 103 genes. One hundred and two SNPs were nominally associated with MI, but the statistical significance did not remain after adjustment for multiple testing. A subset of 940 SNPs from 69 genes were tested against MI risk factors. One hundred and sixty-three SNPs were nominally associated with a MI risk factor and 13 remained significant after adjusting for multiple testing. Of these 13, 11 were associated with apolipoprotein (Apo) B/A1 levels: 8 SNPs from 3 genes were associated with Apo B, and 3 cholesteryl ester transfer protein SNPs were associated with Apo A1. Seven of 8 of the SNPs associated with Apo B levels were nominally associated with MI (P or =0.17). Of the 3 SNPs most significantly associated with MI, rs7412, which defines the Apo E2 isoform, was associated with both a lower Apo B/A1 ratio (P=1.0x10(-7)) and lower MI risk (P=0.0004). Two low-density lipoprotein receptor variants, 1 intronic (rs6511720) and 1 in the 3' untranslated region (rs1433099) were both associated with a lower Apo B/A1 ratio (P

Author-supplied keywords

  • *Polymorphism, Single Nucleotide
  • Alleles
  • Apolipoprotein A-I/blood/genetics
  • Apolipoprotein E2/blood/genetics
  • Apolipoproteins B/blood/genetics
  • Arabs/genetics
  • Asian Continental Ancestry Group/genetics
  • Case-Control Studies
  • Cholesterol Ester Transfer Proteins/blood/genetics
  • European Continental Ancestry Group/genetics
  • Female
  • Genotype
  • Humans
  • Iran
  • Male
  • Middle Aged
  • Myocardial Infarction/*ethnology/*genetics
  • Nepal
  • Phenotype
  • Receptors, LDL/blood/genetics
  • Risk Factors

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Authors

  • S S Anand

  • C Xie

  • G Pare

  • A Montpetit

  • S Rangarajan

  • M J McQueen

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