Genetic variation in microRNA genes and risk of oral premalignant lesions

  • Clague J
  • Lippman S
  • Yang H
 et al. 
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Abstract

MicroRNAs (miRNAs) have been reported to play a key role in oncogenesis and, recently, studies have examined the role miRNAs might play in the risk of premalignant lesions. To our knowledge, no study has investigated the association between miRNA polymorphisms and risk of oral premalignant lesions (OPLs). We genotyped 31 single nucleotide polymorphisms (SNPs) among 21 miRNA-related genes in a case-control study including 136 OPL patients and 136 matched controls. Patients with at least one variant allele of mir26a-1:rs7372209 had a significantly increased risk of OPL (OR, 2.09; 95%CI, 1.23-3.56). Likewise, patients with at least one variant allele of DICER:rs3742330 had a significantly increased risk of OPL (OR, 2.09; 95% CI, 1.03-4.24). To assess the cumulative effects, we performed a combined unfavorable genotype analysis that included all SNPs showing at least a borderline statistical significance. A significant trend of increased risk of OPL with increasing number of unfavorable genotypes was observed (P for trend

Author-supplied keywords

  • Cancer risk
  • Case-control study
  • Genetic variation
  • Oral premalignant lesions
  • microRNA

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Authors

  • J. Clague

  • S.M. Lippman

  • H. Yang

  • M.A.T. Hildebrandt

  • Y. Ye

  • J.J. Lee

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