Genetic variation in the promoter of DNMT3B is associated with the risk of colorectal cancer

  • Bao Q
  • He B
  • Pan Y
 et al. 
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Abstract

DNA methyltransferase-3B (DNMT3B) plays an important role in the generation of aberrant methylation in carcinogenesis. Polymorphisms of the DNMT3B gene may influence DNMT3B enzyme activity on DNA methylation, thereby modulating the susceptibility to colorectal cancer (CRC).

Author-supplied keywords

  • Colorectal cancer (CRC)
  • DNMT3B
  • Polymorphism

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Authors

  • Qian Bao

  • Bangshun He

  • Yuqin Pan

  • Zhipeng Tang

  • Ying Zhang

  • Lili Qu

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