What the genome sequence is revealing about trypanosome antigenic variation.

  • Barry J
  • Marcello L
  • Morrison L
 et al. 
  • 45

    Readers

    Mendeley users who have this article in their library.
  • 47

    Citations

    Citations of this article.

Abstract

African trypanosomes evade humoral immunity through antigenic variation, whereby they switch expression of the gene encoding their VSG (variant surface glycoprotein) coat. Switching proceeds by duplication of silent VSG genes into a transcriptionally active locus. The genome project has revealed that most of the silent archive consists of hundreds of subtelomeric VSG tandem arrays, and that most of these are not functional genes. Precedent suggests that they can contribute combinatorially to the formation of expressed, functional genes through segmental gene conversion. These findings from the genome project have major implications for evolution of the VSG archive and for transmission of the parasite in the field.

Author-supplied keywords

  • Animals
  • Antigens, Protozoan
  • Evolution, Molecular
  • Genetic Variation
  • Genome
  • Trypanosomatina
  • Trypanosomatina: genetics
  • Variant Surface Glycoproteins, Trypanosoma
  • Variant Surface Glycoproteins, Trypanosoma: geneti

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • J D Barry

  • L Marcello

  • L J Morrison

  • a F Read

  • K Lythgoe

  • N Jones

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free