Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease

  • Stein J
  • Hua X
  • Morra J
 et al. 
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Abstract

In a genome-wide association study of structural brain degeneration, we mapped the 3D profile of temporal lobe volume differences in 742 brain MRI scans of Alzheimer's disease patients, mildly impaired, and healthy elderly subjects. After searching 546,314 genomic markers, 2 single nucleotide polymorphisms (SNPs) were associated with bilateral temporal lobe volume (P

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Authors

  • Jason L. Stein

  • Xue Hua

  • Jonathan H. Morra

  • Suh Lee

  • Derrek P. Hibar

  • April J. Ho

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