A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

  • Hampe J
  • Franke A
  • Rosenstiel P
 et al. 
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Abstract

We performed a genome-wide association study of 19,779 nonsynonymous SNPs in 735 individuals with Crohn disease and 368 controls. A total of 7,159 of these SNPs were informative. We followed up on all 72 SNPs with P 0.4), these data suggest that the underlying biological process may be specific to Crohn disease.

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Authors

  • Andre FrankeInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel

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  • Jochen Hampe

  • Philip Rosenstiel

  • Andreas Till

  • Markus Teuber

  • Klaus Huse

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