Skip to content
Journal article

Genome-wide association studies for common diseases and complex traits

Hirschhorn J, Daly M...(+2 more)

Nature Reviews Genetics, vol. 6, issue 2 (2005) pp. 95-108 Published by Nature Publishing Group

  • 4

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.
  • N/A

    Views

    ScienceDirect users who have downloaded this article.
Sign in to save reference

Abstract

Genetic factors strongly affect susceptibility to common diseases and also influence disease-related quantitative traits. Identifying the relevant genes has been difficult, in part because each causal gene only makes a small contribution to overall heritability. Genetic association studies offer a potentially powerful approach for mapping causal genes with modest effects, but are limited because only a small number of genes can be studied at a time. Genome-wide association studies will soon become possible, and could open new frontiers in our understanding and treatment of disease. However, the execution and analysis of such studies will require great care.

Author-supplied keywords

  • Animals
  • Genetic Predisposition to Disease
  • Genetic Variation
  • Genome
  • Humans
  • Linkage Disequilibrium
  • Multifactorial Inheritance
  • Quantitative Trait: Heritable
  • Sequence Analysis: DNA

Find this document

Get full text

Cite this document

Choose a citation style from the tabs below