Genome-wide association study in breast cancer survivors reveals SNPs associated with gene expression of genes belonging to MHC class I and II.

  • Landmark-Hoyvik H
  • Dumeaux V
  • Nebdal D
 et al. 
  • 3


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


INTRODUCTION: We investigated the effect of genetic variation on gene expression in blood from a cohort of BC survivors. Further, we investigated the associations that were specific for BC survivors by performing identical analyses for a group of healthy women and comparing the results. METHODS: eQTL analysis was performed for 288 BC survivors (full data set). Further, using a subset of the data, eQTL analyses were performed on 288 BC survivors and on 81 healthy women separately and results were compared. RESULTS: A large number of associations were observed for the BC survivors, and the expression of human leukocyte antigen genes was found associated with SNPs in 100 genes. The comparison analyses with healthy women revealed associations occurring specifically in BC survivors, and the genes showed enrichment for immune system processes. CONCLUSIONS: The results suggest that the immune system has a different constitution in BC survivors compared to healthy women.

Author-supplied keywords

  • Breast Neoplasms
  • Case-Control Studies
  • Chromosome Mapping
  • Cohort Studies
  • Female
  • Gene Expression
  • Genes, MHC Class I
  • Genes, MHC Class II
  • Genetic Predisposition to Disease
  • Genetic Variation
  • Genome-Wide Association Study
  • Humans
  • Linear Models
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Survivors
  • genetics

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Hege Landmark-Hoyvik

  • Vanessa Dumeaux

  • Daniel Nebdal

  • Eiliv Lund

  • Jorg Tost

  • Yoichiro Kamatani

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free