Genome-wide association study in breast cancer survivors reveals SNPs associated with gene expression of genes belonging to MHC class I and II.

  • Landmark-Hoyvik H
  • Dumeaux V
  • Nebdal D
 et al. 
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Abstract

INTRODUCTION: We investigated the effect of genetic variation on gene expression in blood from a cohort of BC survivors. Further, we investigated the associations that were specific for BC survivors by performing identical analyses for a group of healthy women and comparing the results. METHODS: eQTL analysis was performed for 288 BC survivors (full data set). Further, using a subset of the data, eQTL analyses were performed on 288 BC survivors and on 81 healthy women separately and results were compared. RESULTS: A large number of associations were observed for the BC survivors, and the expression of human leukocyte antigen genes was found associated with SNPs in 100 genes. The comparison analyses with healthy women revealed associations occurring specifically in BC survivors, and the genes showed enrichment for immune system processes. CONCLUSIONS: The results suggest that the immune system has a different constitution in BC survivors compared to healthy women.

Author-supplied keywords

  • Breast Neoplasms
  • Case-Control Studies
  • Chromosome Mapping
  • Cohort Studies
  • Female
  • Gene Expression
  • Genes, MHC Class I
  • Genes, MHC Class II
  • Genetic Predisposition to Disease
  • Genetic Variation
  • Genome-Wide Association Study
  • Humans
  • Linear Models
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Survivors
  • genetics

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Authors

  • Hege Landmark-Hoyvik

  • Vanessa Dumeaux

  • Daniel Nebdal

  • Eiliv Lund

  • Jorg Tost

  • Yoichiro Kamatani

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