Journal article

Genome-wide transcriptome analysis in murine neural retina using high-throughput RNA sequencing

Gamsiz E, Ouyang Q, Schmidt M, Nagpal S, Morrow E ...see all

Genomics, vol. 99 (2012) pp. 44-51

  • 7


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.
Sign in to save reference


Genome-wide characterization of the retinal transcriptome is central to understanding development, physiology and disorders of the visual system. Massively parallel, short-read sequencing of mRNA libraries was used to generate an extensive map of the transcriptome of the adult, murine neural retina. RNA-seq data strongly corroborates prior transcriptome studies by microarray and SAGE. However, several novel features of the retinal transcriptome were discovered. For example, retinal disease genes were discovered to be among the most highly expressed in the transcriptome. We also demonstrate other interesting features of the retinal transcriptome, for example, that the retina appears to employ a very specific and restricted set of synaptic vesicle genes, and also that there is persistence of expression of a majority of "neurodevelopmental" genes into adulthood. Retina transcriptome studies utilizing novel sequencing methods have been highly informative and these data may also serve as a resource for the community of researchers.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in


  • E. D. Gamsiz

  • Q. Ouyang

  • M. Schmidt

  • S. Nagpal

  • E. M. Morrow

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free