Genomic analysis of protein-DNA interactions in bacteria: Insights into transcription and chromosome organization

  • Wade J
  • Struhl K
  • Busby S
 et al. 
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Abstract

Chromatin immunoprecipitation (ChIP) is a powerful method to measure protein-DNA interactions in vivo, and it can be applied on a genomic scale with microarray technology (ChIP-chip). ChIP-chip has been used extensively to map DNA-protein interactions across eukaryotic chromosomes. Here we review recent applications of ChIP-chip to the study of bacteria, which provide important and unexpected insights into transcription and chromosome organization.

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Authors

  • Joseph T. Wade

  • Kevin Struhl

  • Stephen J.W. Busby

  • David C. Grainger

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