Genomic risk profiling: Attitudes and use in personal and clinical care of primary care physicians who offer risk profiling

  • Haga S
  • Carrig M
  • O'Daniel J
 et al. 
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BACKGROUND: Genomic risk profiling involves the analysis of genetic variations linked through statistical associations to a range of disease states. There is considerable controversy as to how, and even whether, to incorporate these tests into routine medical care.

OBJECTIVE: To assess physician attitudes and uptake of genomic risk profiling among an 'early adopter' practice group.

DESIGN: We surveyed members of MDVIP, a national group of primary care physicians (PCPs), currently offering genomic risk profiling as part of their practice.

POPULATION: All physicians in the MDVIP network (N = 356)

RESULTS: We obtained a 44% response rate. One third of respondents had ordered a test for themselves and 42% for a patient. The odds of having ordered personal testing were 10.51-fold higher for those who felt well-informed about genomic risk testing (p 
CONCLUSIONS: Our findings demonstrate that respondent familiarity was a key predictor of physician ordering behavior and clinical utility was a primary concern for genomic risk profiling. Educational and interpretive support may enhance uptake of genomic risk profiling.

Author-supplied keywords

  • education
  • genetic testing
  • primary care
  • risk

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  • Susanne B. Haga

  • Madeline M. Carrig

  • Julianne M. O'Daniel

  • Lori A. Orlando

  • Ley A. Killeya-Jones

  • Geoffrey S. Ginsburg

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