Glial cell migration directed by axon guidance cues

  • Tsai H
  • Miller R
  • 82

    Readers

    Mendeley users who have this article in their library.
  • 59

    Citations

    Citations of this article.

Abstract

Widespread myelination by oligodendrocytes is essential for the normal functioning of the vertebrate CNS. Oligodendrocyte precursors initially arise in restricted regions of the neuroepithelium and migrate relatively long distances to their final destinations. The signals that guide this migration have remained poorly understood, but recent studies suggest that glial precursors use similar molecular cues to those that guide axons through the complex terrain of the developing CNS. For example, in the developing optic nerve, glial-precursor migration from the brain towards the retina is guided by netrin-1 and semaphorin 3a. These studies suggest a novel mechanism governing glial precursor migration and provide new insights into development and the potential to direct CNS injury repair.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Hui Hsin Tsai

  • Robert H. Miller

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free