Glucocorticoid receptor polymorphisms in major depression.

  • Claes S
  • 1

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

Major depressive disorder (MDD) often appears after exposure to acute or chronic stress, and dysfunction of stress response systems, such as the hypothalamic-pituitary-adrenal (HPA) axis, is thought to be a key element of MDD neurobiology. The glucocorticoid receptor (GR) is the most important regulator of the HPA axis negative feedback system, and GR sensitivity has been shown to be reduced in MDD in both in vitro and in vivo studies. Transgenic animals with partial impairment of GR function show behavioral changes consistent with MDD. This makes the GR gene a prime candidate for research into the genetic background of MDD. Several single nucleotide polymorphisms (SNPs) have been detected that have specific effects on GR function, metabolic parameters, and HPA axis function in response to stress. Genetic association studies have yielded preliminary evidence for a role of these genetic variations in the genetic vulnerability for MDD. Taken together, the evidence for a role of GR and the GR gene in the neurobiology of MDD is building rapidly. (PsycINFO Database Record (c) 2016 APA, all rights reserved)

Author-supplied keywords

  • 2009
  • Chronic Stress
  • Genetics
  • Glucocorticoids
  • Major Depression
  • Neural Receptors
  • Polymorphism
  • Receptor Binding
  • Stress
  • acute stress
  • chronic stress
  • glucocorticoid receptor
  • glucocorticoid receptor gene
  • glucocorticoid receptor sensitivity
  • hypothalamic-pituitary-adrenal axis
  • major depressive disorder
  • neurobiology
  • nucleotide polymorphisms
  • stress response systems

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Stephan Claes

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free