Glucocorticoid receptors modulate mitochondrial function: A novel mechanism for neuroprotection.

  • Du J
  • McEwen B
  • Manji H
  • 30

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

It has become increasingly clear that glucocorticoid (GC) signaling not only comprises classic nuclear receptor binding-that is, glucocorticoid receptors (GRs) to their response element in the nucleus-but also involves rapid, non-genomic efforts to regulate signaling cascades and other cell functions in the cytoplasm as well as other cell organelles. In a recent study, we found that GRs form a complex with B-cell lymphoma 2 (Bcl-2), trans- locate to mitochondria in response to corticosterone (CORT), and modulate mitochondrial calcium and oxidation in an inverted U-shaped manner. It is also well established that steroid and thyroid hormone receptors regulate mitochondrial function to protect cells against various challenges and modulate synaptic plasticity. Here, we explore how such work reveals a fundamental mechanism whereby GCs regulate mitochondrial functions, and provides a mechanistic basis for therapeutic methods to rescue mitochondrial dysfunction during chronic stress or related psychiatric and neurodegenerative disorders.

Author-supplied keywords

  • bcl-2
  • classic nuclear receptor binding
  • clear that glucocorticoid
  • gc
  • glucocorticoid
  • glucocorticoid receptors
  • grs
  • it has become increasingly
  • mitochondria
  • mood disorders
  • neuroprotection
  • nuclear receptor
  • plasticity
  • signaling not only comprises
  • steroid
  • that is
  • to their response element

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Jing Du

  • Bruce McEwen

  • Husseini K Manji

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free