Glucose selective Surface Plasmon Resonance-based bis-boronic acid sensor

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Abstract

Saccharides-a versatile class of biologically important molecules-are involved in a variety of physiological and pathological processes, but their detection and quantification is challenging. Herein, surface plasmon resonance and self-assembled monolayers on gold generated from bis-boronic acid bearing a thioctic acid moiety, whose intramolecular distance between the boronic acid moieties is well defined, are shown to detect d-glucose with high selectivity, demonstrating a higher affinity than other saccharides probed, namely d-galactose, d-fructose and d-mannose. © 2013 The Royal Society of Chemistry.

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Stephenson-Brown, A., Wang, H. C., Iqbal, P., Preece, J. A., Long, Y., Fossey, J. S., … Mendes, P. M. (2013). Glucose selective Surface Plasmon Resonance-based bis-boronic acid sensor. Analyst, 138(23), 7140–7145. https://doi.org/10.1039/c3an01233f

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