Glycolysis and cellular immortalization

  • Kondoh H
  • Lleonart M
  • Gil J
 et al. 
  • 24


    Mendeley users who have this article in their library.
  • 16


    Citations of this article.


A prominent feature of immortal cells and stem cells is their resistance to oxidative stress. By contrast, primary cells undergo senescence when grown for extended periods in tissue culture or exposed to agents that increase production of reactive oxygen species (ROS). We recently found that enhanced glycolysis enables primary mouse cells to avoid senescence, by protecting them from oxidative damage, and that immortal ES cells have intrinsically high levels of glycolysis. Thus, in cancer cells, immortality could be the driving force behind the Warburg effect. © 2005 Elsevier Ltd. All rights reserved.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Hiroshi Kondoh

  • Matilde E. Lleonart

  • Jesus Gil

  • David Beach

  • Gordon Peters

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free