Glycomics and Mass Spectrometry

  • Dell A
  • Jang-lee J
  • Pang P
 et al. 
  • 28

    Readers

    Mendeley users who have this article in their library.
  • 66

    Citations

    Citations of this article.

Abstract

There is an increasing body of evidence indicating that glycans are implicated in numerous bio- logical processes such as cell–cell interactions, intracellular signaling, and immune response. Glycomics emerges from the necessity to understand the mechanisms underlying the inter- actions responsible for these activities. The term glycomics is used to describe experimental approaches to studying the structure and function of the glycomes of fluids, cells, tissues, organs etc. Glycomics embraces a variety of technologies amongst which mass spectrometry (MS) plays a pivotal role because it is themethod of choice for defining the primary structures of glycopolymers. This chapter provides an insight into MS-based structural strategies that are best suited to studying complex glycomes.

Author-supplied keywords

  • Glycomics
  • Glycopeptides
  • Glycoproteomics
  • Mass spectrometry
  • N-glycans
  • Nano liquid chroma- tography
  • O-glycans
  • Profiling
  • Structural analysis
  • Tandem mass spectrometry

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text

Authors

  • Anne Dell

  • Jihye Jang-lee

  • Poh-choo Pang

  • Simon Parry

  • Mark Sutton-smith

  • Berangere Tissot

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free