Glycoside modification of oleanolic acid derivatives as a novel class of anti-osteoclast formation agents

  • Li J
  • Chen S
  • Zhao Y
 et al. 
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Oleanolic acid, a natural product, possesses an anti-osteoclast formation activity. Targeting at discovery of novel and potent anti-bone resorption agents, 22 glycosides of oleanolic acid derivatives (including d-galactopyranosides, d-glucopyranosides, d-xylopyranoses, d-arabopyranoses and d-glycuronic acids) were synthesized at phase-transfer-catalyzed conditions (K2CO3, Bu4NBr, CH2Cl2-H2O) and their inhibitory activity on the formation of osteoclast-like multinucleated cells (OCLs) induced by 1α, 25-dihydroxy vitamin D3was evaluated in a co-culture assay system. The structure-activity relationships of these compounds were also discussed. © 2009 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • Glycoside derivatives
  • Inhibitory activity
  • Oleanolic acid
  • Osteoclast formation

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