Glycoside modification of oleanolic acid derivatives as a novel class of anti-osteoclast formation agents

  • Li J
  • Chen S
  • Zhao Y
 et al. 
  • 19

    Readers

    Mendeley users who have this article in their library.
  • 31

    Citations

    Citations of this article.

Abstract

Oleanolic acid, a natural product, possesses an anti-osteoclast formation activity. Targeting at discovery of novel and potent anti-bone resorption agents, 22 glycosides of oleanolic acid derivatives (including d-galactopyranosides, d-glucopyranosides, d-xylopyranoses, d-arabopyranoses and d-glycuronic acids) were synthesized at phase-transfer-catalyzed conditions (K2CO3, Bu4NBr, CH2Cl2-H2O) and their inhibitory activity on the formation of osteoclast-like multinucleated cells (OCLs) induced by 1α, 25-dihydroxy vitamin D3was evaluated in a co-culture assay system. The structure-activity relationships of these compounds were also discussed. © 2009 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • Glycoside derivatives
  • Inhibitory activity
  • Oleanolic acid
  • Osteoclast formation

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free