Gold nanorods mediate tumor cell death by compromising membrane integrity

  • Tong L
  • Zhao Y
  • Huff T
 et al. 
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Abstract

Folate-conjugated gold nanorods targeted to tumor cell surfaces produced severe membrane damage upon near-infrared irradiation. Photoinduced injury to the plasma membrane resulted in a rapid increase in intracellular calcium (shown in green) with subsequent disruption of the actin network, featured prominently by the formation of membrane blebs.

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Authors

  • Ling Tong

  • Terry B. Huff

  • Matthew N. Hansen

  • Alexander Wei

  • Ji Xin Cheng

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