Cyclohexanone and cyclohexanol are oxidized to adipic acid in high yield with aqueous 30% H2O2 in the presence of H 2WO4 as a catalyst under organic solvent- and halide-free conditions. It is important that no solvent is used in order to achieve high reactivity in this heterogeneous reaction. The use of t-butyl alcohol or dioxane as a solvent (homogeneous conditions) significantly decreases the yield of adipic acid from cyclohexanone. This ketone-to-dicarboxylic acid conversion is applicable to five- to eight-membered cyclic ketones. No operational problems are foreseen for a large-scale version of this green process.
CITATION STYLE
Usui, Y., & Sato, K. (2003). A green method of adipic acid synthesis: Organic solvent- and halide-free oxidation of cycloalkanones with 30% hydrogen peroxide. Green Chemistry, 5(4), 373–375. https://doi.org/10.1039/b305847f
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