Growth inhibition of Candida species and Aspergillus fumigatus by statins

  • Macreadie I
  • Johnson G
  • Schlosser T
 et al. 
  • 35


    Mendeley users who have this article in their library.
  • 64


    Citations of this article.


Statins are a class of drugs widely used for lowering high cholesterol levels through their action on 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme in the synthesis of cholesterol. We studied the effects of two major statins, simvastatin and atorvastatin, on five Candida species and Aspergillus fumigatus. The statins strongly inhibited the growth of all species, except Candida krusei. Supplementation of Candida albicans and A. fumigatus with ergosterol or cholesterol in aerobic culture led to substantial recovery from the inhibition by statins, suggesting specificity of statins for the mevalonate synthesis pathway. Our findings suggest that the statins could have utility as antifungal agents and that fungal colonization could be affected in those on statin therapy.

Author-supplied keywords

  • Antifungal
  • Atorvastatin
  • Cholesterol
  • Ergosterol
  • HMG-CoA reductase inhibition
  • Simvastatin

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Ian G. Macreadie

  • Georgia Johnson

  • Tanja Schlosser

  • Peter I. Macreadie

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free