HDAC6 a new cellular stress surveillance factor

  • Matthias P
  • Yoshida M
  • Khochbin S
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Less than a decade has passed since HDAC6 was first identified and regarded as an unusual histone deacetylase harbouring two catalytic domains. Early demonstration of its cytoplasmic localisation, its ubiquitin-binding and its tubulin-deacetylase activities took HDAC6 far away from everything known to involve other histone-deacetylases. Recent discoveries confirmed the very unique functions of HDAC6 among deacetylases and pointed to this protein as a master regulator of cell response to cytotoxic assaults. HDAC6 appears both as a sensor of stressful stimuli and as an effector, which, thanks to its wide range of activities, mediates and coordinates appropriate cell responses.

Author-supplied keywords

  • Acetylation
  • Aggresome
  • Autophagy
  • HSF1
  • HSP90
  • Microtubule
  • Neurodegenerative disease
  • p97/VCP

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  • Patrick Matthias

  • Minoru Yoshida

  • Saadi Khochbin

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