The complexity and novelty of public health genomics poses a challenge to ensure effective and responsible translation of genome-based information for the benefit of population health. The aim of this article is to provide literature-based insight into how the concept of health literacy can act as a catalyst for the translation process and to comment on the necessity to adapt new perspectives in a rapidly changing world, such as e.g. the health literacy-friendly approach of Google. Taking advantage of the potential of health literacy in the population along with a recognized role of health professionals as knowledge brokers and 'nudges' will benefit the efficiency and responsibility of translating genome-based knowledge.
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