Health-related quality-of-life assessment in patients with cutaneous T-cell lymphoma.

  • Demierre M
  • Tien A
  • Miller D
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Abstract

OBJECTIVE: To measure and evaluate the health-related quality of life (HRQOL) in patients with cutaneous T-cell lymphoma (CTCL), a visible cutaneous malignancy that may have a profound effect on patients' lives. DESIGN: Monocenter, cross-sectional study. SETTING: The Skin Oncology Program, Department of Dermatology, and the Photopheresis Unit of Boston Medical Center. PATIENTS: A total of 22 adult patients with confirmed CTCL. MAIN OUTCOME MEASURES: (1) Evaluation of general oncologic and skin disease-specific HRQOL using, respectively, the Functional Assessment of Cancer Therapy-General (FACT-G) and Skindex-29 profiles; (2) assessment of HRQOL association with disease stage (early stage, IA-IIA; late stage, IIB-IVB). RESULTS: Patients with more advanced CTCL stages reported more effects on general health (FACT-G), particularly in the physical, emotional, and functional domains (P < .05). Patients with early-stage CTCL reported better skin-specific HRQOL overall (Skindex-29; P = .002) and for each specific domain than did patients with late-stage disease. The Skindex-29 scales had high internal consistency, and the confirmatory factor structure was similar to that of previous studies. CONCLUSIONS: The HRQOL of patients with CTCL can be evaluated using the Skindex-29 and FACT-G instruments. Patients with more advanced stages of CTCL had lower HRQOL scores.

Author-supplied keywords

  • 80 and over
  • Adaptation
  • Adult
  • Aged
  • Combined Modality Therapy
  • Cross-Sectional Studies
  • Cutaneous
  • Cutaneous: diagnosis
  • Cutaneous: psychology
  • Cutaneous: therapy
  • Female
  • Humans
  • Lymphoma
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Physiological
  • Probability
  • Prognosis
  • Psychological
  • Quality of Life
  • Sickness Impact Profile
  • Skin Neoplasms
  • Skin Neoplasms: diagnosis
  • Skin Neoplasms: psychology
  • Skin Neoplasms: therapy
  • T-Cell

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Authors

  • Marie-France Demierre

  • Amy Tien

  • Donald Miller

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